Peter Kochunov1, Carlos Castro2, Gerald Schatten3, David Purdy4, Hsiao-Ying Wey1, Duff Davis1
1Reseach Imaging Institute, UTHSCSA, san antonio, TX, United States; 2Ob / Gyn and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; 3Pittsburgh Development Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; 4Siemens Healthcare USA, Malvern, PA , United States
While the teratogenic properties of alcohol are well known, the mechanisms by which alcohol-induced damage is produced in the CNS are still largely unknown. We present findings of changes in dynamic susceptibility contrast (DSC) in fetal brain of a non-human primate (baboon) during a protocol designed to approximate a binge drinking episode. Signal changes in the brain and uterus/placenta were compared using a pulse sequence protocol with high temporal and spatial resolution, showing that gadodiamide entered fetal cerebral circulation following alcohol administration.