Erwin
Lambert Blezer1, Yolanda S. Kap2, Jan Bauer3,
Bert L. 't Hart2
1Image Sciences Institute, University
Medical Center Utrecht, Utrecht, Netherlands; 2Department of
Immunobiology, Biomedical Primate Research Center, Rijswijk, Netherlands; 3Brain
Research Institute, University of Vienna, Vienna, Austria
Cortical
pathology is an important feature of MS. However visualization with MRI is
poor although sensitivity is increased using FLAIR and Double Inversion
Recovery (suppression of CSF and white matter) experiments. Various inversion
recovery experiments were tested ex vivo on brains of marmoset with MS, which
develop cortical lesions, in their ability to improve cortical lesion
detection. Experiments included settings of inversion times in which CSF,
white or grey matter was suppressed and a DIR experiment in which both white
and grey matter was suppressed. Cortical lesions were best visualized after
suppression of white matter or in the DIR experiment.