Ying-Jr Chen1, Joong Hee Kim1, Jian Wang1, Tsang-Wei Tu, 12, Sheng-Kwei Song1
1Radiology, Washington University in St. Louis, Saint Louis, MO, United States; 2Mechanical, Aerospace and Structural Engineering, Washington University in St. Louis, Saint Louis, MO, United States
The sensitivities of detecting white matter injury using 6 ms and 38 ms diffusion time were examined in the present study. We demonstrated that increased diffusion time in diffusion tensor imaging measurements improves the sensitivity of detecting axonal injury and myelin damage in cuprizone treated mice. In the cuprizone model of demyelination, axonal injury was seen as significantly decreased axial diffusivity at both 6 and 38 ms diffusion time with more significantly decreased axial diffusivity observed at longer diffusion time.