Bensheng Qiu1, Daohai Xie2, Piotr Walczak3, Xubin Li, Jesus Ruiz-Cabello3, Satoshi Minoshima, Jeff W.M. Bulte3, Xiaoming Yang
1University of Washington,
Neural stem cells (NSC) have been recognized as cellular vehicles for treatment of invasive brain tumors. MRI is a unique non-invasive tool to monitor the migration of stem cells labeled with MR contrast agents, such as superparamagnetic iron oxide (SPIO) particles. Pervious studies have confirmed that magnetosonoporation (MSP) can instantly labeled SPIO into stem cells. The aim of this study was to validate the feasibility of MRI of MSP-labeled NSC migration to gliomas in vivo.