Anitha Priya Krishnan1, Delphine Davis2, Paul Okunieff3, Walter G. O'Dell3
1Biomedical Engineering, University of Rochester, Rochester, NY, United States; 2Imaging Sciences, University of Rochester, Rochester, NY, United States; 3Radiation Oncology, University of Rochester, Rochester, NY, United States
The current methods for determining the treatment margins for stereotactic radiotherapy of gliomas is inadequate as the tumor often recurs at the boundary of the treatment margin. The areas of high normalized cell migration predicted by our random walk model coincide with the direction along which the tumor recurs. Here we have established that there is a statistically significant correlation between the model predictions and the recurrence site and the average normalized cell concentration in the recurrence site is higher than the normalized cell concentration in 78% of the voxels on a surface equidistant from the primary tumor surface.