Virendra R. Desai1, Qiang Shen1, Timothy Q. Duong1
1Research Imaging Institute,
Ophthalmology/Radiology, UT Health Science
Acute diffusion data has been used to predict ischemic tissue fate on a pixel-by-pixel basis. Previous predictions however were made based on acute MRI data from a single time point. This study proposes a novel approach to incorporate the temporal characteristics of acute ADC (apparent diffusion coefficient) changes to characterize tissue fate based on a pixel-by-pixel basis. This approach was tested on rat stroke models subjected to permanent and 60-min middle cerebral artery occlusion (MCAO). We concluded that there were distinct temporal patterns that determined tissue salvageability.