Young Ro Kim1, Xiang Fan2, Guangping Dai1, Jeong Kon Kim3, Bruce R. Rosen1, xiaoying Wang2
1Radiology, Martinos Center for Biomedical Imaging / Massachusetts General Hospital, Charlestown, MA, United States; 2Radiology, Neuroprotection Research laboratory / Massachusetts General Hospital, Charlestown, MA, United States; 3Radiology, Asan Medical Center, Seoul, Korea, Republic of
Tissue plasminogen activator (tPA) has been frequently used for treating acute ischemic stroke based on re-canalization, reopening of occluded vessels for the reinstitution of regional blood perfusion. Despite the promising clinical outcomes, exogenous tPA may worsen the ischemia-induced blood brain-barrier disruption, elevate risks of intracranial hemorrhage, and in part consequently reduces the therapeutic time window. Therefore, it is critically important to understand the overall effects of tPA treatment on cerebrohemodynamics. In this study, we investigated the vasoreactivity in response to intravenously administered tPA and to systemic hypercapnia before and after tPA using a permanent focal stroke rat model.