David Matthew Carpenter1, Emily L. Eaves1, Cheuk Ying Tang1, Gudrun Lange2,3, Johnny Ng4, Nancy L. Fiedler5
1Radiology, Mount Sinai School of Medicine, New York, United States; 2Psychiatry, UMDNJ-New Jersey Medical School, Newark, NJ; 3Radiology, UMDNJ-New Jersey Medical School, West Orange, NJ, United States; 4Radiology, City Colege ofl New York, Bronx, NY, United States; 5Environmental and Occupational Medicine, UMDNJ- Robert Wood Johnson Medical School, Piscataway, NJ, United States
In this report BOLD fMRI to investigate the functional deficits of subjects with long-term occupational solvent exposure. Subjects underwent fMRI while performing a Sternberg task and N-back working memory task. We used an exploratory voxel-wise and an ROI analysis to test the hypothesis that the occupationally exposed subjects show hypo-activation in regions associated with working memory when compared to a carefully matched control group. the results suggest that prolonged occupational solvent exposure is related to a decreased activation in regions associated with working memory.