William Dominguez-Viqueira1,2, Matthew S. Fox, 1,3, Giles E. Santyr2,4
1Imaging Laboratories, Robarts Research Institute, London, Ontario, Canada; 2Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada; 3Department of Physics and Astronomy, University of Western Ontario, London, Ontario, Canada; 4Department of Medical Imaging, University of Western Ontario, London, Ontario, Canada
The maximum SNR in Hyperpolarized Noble Gas (HNG) MR imaging of rodent lung is expected to be at high fields (>3T). However, SNR improvements of up to 300% have been demonstrated in rat lung at 73.5mT using Litz-wire coils. In this work the SNR for HNG MRI of rat lung was investigated theoretically and in vivo, using multi-turn Litz-wire coils at 73.5mT and compared to images obtained at 3T using 129Xe and 3He. The use of Litz-wire coils significantly reduces the advantage (from factor ten to a factor of two) of using high fields for HNG imaging of rat lungs.