Jerome Cote1, Luc Tremblay1,
Fernand Jr Gobeil2, David Fortin3, Martin Lepage1
1Nuclear medecine and radiobiology,
Universit de Sherbrooke, Sherbrooke, QC, Canada; 2Pharmacology,
Universit de Sherbrooke, Sherbrooke, QC, Canada; 3Surgery,
Universit de Sherbrooke, Sherbrooke, QC, Canada
Dynamic
contrast-enhanced magnetic resonance imaging with intravenous Gd-DTPA or
Gadomer was used to monitor the selective increase of blood-brain barrier
permeability (BBB) at the tumor of glioma-bearing rats, induced by either the
natural kinin B1 receptor (B1R) agonist LDBK, or NG29, a synthetic
high-affinity agonist. Post-contrast images revealed that only NG29 modulates
topographic uptake profiles of both contrast agents within rat glioma and
brain tissue surrounding the tumor, as observed by increase of both contrast
agents distribution volume and mean Gd concentration in the implanted hemisphere.
Our results confirm the use of B1R agonists to permeabilize the BBB around
tumors.