Jin Zhang1, Sungheon Kim2
1Department of Finance and Risk Engineering, Polytechnic Institute of New York University, New York, NY, United States; 2Center for Biomedical Imaging, Radiology, NYU School of Medicine, New York, NY, United States
Extracting physiologically relevant parameters from DCE-MRI data is still a challenging problem since the effect of contrast agent is indirectly measured in proton MRI. The purpose of the current study was to use a numerical simulation method to generate DCE-MRI data with water exchange effect and to investigate its effects on the pharmacokinetic model parameters. Realistic MRI data were simulated using the BTEX model and a three-site two-exchange model. Two conventional pharmacokinetic models were fitted to the simulated data. The preliminary results demonstrate the significance of the water exchange effect in estimating pharmacokinetic model parameters.