Jin Zhang1, Sungheon Kim2
1Department of Finance and Risk Engineering,
Polytechnic Institute of New York University, New York, NY, United States; 2Center
for Biomedical Imaging, Radiology, NYU School of Medicine, New York, NY,
United States
Extracting
physiologically relevant parameters from DCE-MRI data is still a challenging
problem since the effect of contrast agent is indirectly measured in proton
MRI. The purpose of the current study was to use a numerical simulation
method to generate DCE-MRI data with water exchange effect and to investigate
its effects on the pharmacokinetic model parameters. Realistic MRI data were
simulated using the BTEX model and a three-site two-exchange model. Two
conventional pharmacokinetic models were fitted to the simulated data. The
preliminary results demonstrate the significance of the water exchange effect
in estimating pharmacokinetic model parameters.