Abstract #2944

Sensitivity of MRI Resonance Frequency to the Orientation of Brain Tissue Microstructure

Jongho Lee¹, Karin Shmueli¹, Masaki Fukunaga¹, Peter van Gelderen¹, Hellmut Merkle¹, Afonso C. Silva², Jeff H. Duyn¹

¹Advanced MRI/LFMI/NINDS, National Institutes of Health, Bethesda, MD, United States; ²CMU/LFMI/NINDS, National Institutes of Health, Bethesda, MD, United States

Here we demonstrate microstructural orientation affects the MRI resonance frequency. The experiment was designed to avoid macroscopic susceptibility effect to identify true microstructural effect. We suggest an origin related to anisotropic susceptibility.