Rahul Sarkar1, Alan R. Moody1,2, James Q. Zhan2, General Leung1,2
Variable flip angle (VFA) methods using two optimized flip angles have become popular for in-vivo T1 mapping within a limited range of a specific T1 of interest. The range limitation in this approach is generally due to bias against long T1s in the signal-dynamic range product used for flip angle optimization. This study presents a new strategy for flip angle pair selection that mitigates this bias to provide highly uniform accuracy and precision across the biological T1 range. In using only two flip angle acquisitions, this method represents a rapid approach to wide-range VFA T1 mapping.