Sung-Tak Hong1, Dvid Zsolt Balla1, Changho Choi2, Rolf Pohmann1
1High-Field Magnetic Resonance Center , Max-Planck Institute for Biological Cybernetics, Tuebingen, Baden-Wuerttemberg, Germany; 2Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States
Localized in vivo 1H NMR spectroscopy requires significantly high number of averages compared to other MR imaging techniques. Precise analysis on spectra obtained at 16.4T was performed to determine the minimal number of averages, necessary for quantifying nineteen metabolites with average CRLBs of below 20%. The results demonstrated that 64 averages were sufficient to quantify most metabolites reliably except weakly represented metabolites such as alanine, glycine and phosphorylcholine.