Dietsje D. Jolles1,2, Mark A. Van Buchem2,3,
Eveline A. Crone, 3,4, Serge A. Rombouts, 23
1Leiden Institute for Brain and
Cognition (LIBC), Leiden , Netherlands; 2Department of Radiology,
Leiden University Medical Centre, Leiden, Netherlands; 3Leiden
Institute for Brain and Cognition (LIBC), Leiden, Netherlands; 4Developmental
and Educational Psychology, Leiden University, Leiden, Netherlands
In
the present study we investigated voxel-wise whole-brain functional
connectivity in children (11-13 years) and adults (19-25 years), without a
priori restriction to specific seed regions or networks. In addition we
examined to what extent observed changes in functional brain connectivity
could be explained by changes in local grey matter. We show that networks in
children were more widespread than adult networks. Moreover, several networks
showed altered connectivity in children compared to adults. The majority of
the observed changes in functional connectivity could not be explained by
changes in grey matter volume.