1Brain Imaging Research Center, Univ. of Pittsburgh and Carnegie Mellon University, Pittsburgh, PA, United States
Motion correction is critical in diffusion weighted (DW) imaging, but the motion correction quality depends on the accurate motion estimation of the DW images. However, the motion estimation of the DW images can be sensitive to the anisotropic white matter. This has been confirmed using the DW images obtained from an anesthetized and immobilized monkeys head and from a volunteers head. The error in the motion estimation was increased significantly at a higher b value such as b=2400 s/mm2. It is required to develop a new method of motion estimation that is insensitive to the white matter anisotropy.