Junzhong Xu1, Ha-Kyu Jeong1, Mark D. Does1, Adam W. Anderson1, Li Min Chen1, John C. Gore1
1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States
The FA dependence on diffusion time was studied using temporal diffusion spectroscopy, which employs an oscillating gradient spin echo sequence and has the ability to probe much shorter diffusion times. A clear dependence of white matter factional anisotropy on effective diffusion time has been observed in a fixed monkey brain. The results were also predicted by computer simulations. The dependence observed in this study provides a means to probe diffusion restriction and hindrance at sub-cellular length scales, e.g. intracellular structures, and may provide insights into the microstructure of biological tissues and clarify the origins of anisotropy diffusion in white matter.