Irne Troprs1,2, Nicolas Pannetier, 23, Sylvie D. Grand, 2,4, Alexandre Krainik, 2,4, Jean-Franois Le Bas, 2,4, Emmanuel L. Barbier, 23
1Unit IRM 3T, IFR1, La Tronche - Grenoble, France; 2Universite Grenoble 1, Grenoble, France; 3U836, INSERM, Grenoble, France; 4Neuroradiology, Grenoble Hospital, Grenoble, France
Estimate of relative Cerebral Blood Volume (rCBV) obtained with DSC methods suffers from contrast agent (CA) extravasation in brain tumors. The aim of this study is to compare a data processing method accounting for CA dilution with the pre-load approach. In nine patients, a DSC protocol was performed twice within the same session. A gamma-variate fit was used to compute rCBV maps, with and without considering the dilution. This study suggests that the dilution method is relevant when CA pre-load is performed and that normalization of rCBV estimates by white matter values should be handled with care.