Hiroyuki Kabasawa1, Malancha Hore2, Patrice Hervo3, Tetsuji Tsukamoto1
1Japan Applied Science Laboratory, GE Healthcare Japan, Hino, Tokyo, Japan; 2MR Engineering, GE Healthcare, Bangalore, India; 3MR Clinical Development, GE Healthcare, Buc, France
Post-processing correction methods have been proposed to correct this contrast leakage effect in disrupted BBB and to obtain accurate CBV estimation from DSC data. The estimated leakage effect from DSC can vary with the reference time course used in the post-processing. Here, we evaluated the impact of reference time course to estimate the leakage effect using numerical simulation and clinical data. This study showed that appropriate selection of reference time course is an important factor to obtain reasonable contrast leakage index using DSC MRI. Reference time course with wider width may introduce false positive signal in leakage map.