Lyubov Ostrovska1, Mohammad Hedayati2,
Christine Cornejo2, Yoshinori Kato1, Dmitri Artemov1,
Theodore L. DeWeese2, Robert Ivkov2
1The Russell H. Morgan Department of
Radiology and Radiological Science, The Johns Hopkins University School of
Medicine, Baltimore, MD, United States; 2Department of
Radiation Oncology & Molecular
Radiation Sciences, The Johns Hopkins University School of Medicine
The
goal of this study is to sensitize tumors to radiation therapy with heat
generated by magnetic bionized nanoferrite (BNF)-nanoparticles within stem
cells that home to hypoxic areas in tumors. Previously, we demonstrated that
in mouse models of prostate cancer intravenously injected mesenchymal stem
cells migrate to tumors, home to hypoxic areas, and participate in tumor
neovasculogenesis. It was also demonstrated that heating of tumor-bearing
mice injected with BNF-particles resulted in tumor size reduction and delayed
tumor growth. We aim to develop methods for stem cell-based delivery of
BNF-nanoparticles to hypoxic areas in tumors for hyperthermic sensitization
to irradiation.