Elena Torres1, Enzo Terreno1, Roberta Cavalli2, Franco Fedeli3, Francesco Mainini1, Roberta Napolitano1, Silvio Aime1
1Department of Chemistry and Molecular Imaging Center, University of Torino, Torino, Italy; 2Department of Drug Science and Technology, University of Torino, Italy; 3Bioindustry Park of Canavese, Italy
Liposomes occupy a leading role in biomedical field being successfully used since a long time as drug-delivery systems. These nanovesicles can be properly formulated in order to release the entrapped material as a consequence of a specific endogenous stimulus (e.g. acidification, change in redox potential or concentration of specific enzymes) that characterizes the early asymptomatic stage of many diseases. In this contribution, a novel class of paramagnetic pH sensitive liposomes with improved formulations are presented and their basic MRI properties evaluated both in vitro and in vivo on tumor animal model on mice.