Partick Rich1, Huiling Peng2,
Jewell Thomas2, Joseph Mettenburg3, Tammie Benzinger3,
John Morris2, David Balota4, Beau Ances5
1Psychology, Grinnell College,
Grinnell, IO, United States; 2Neurology, Washington University in
St. Louis, St. Louis, MO, United States; 3Radiology, Washington
University in St. Louis, St. Louis, MO, United States; 4Psychology,
Washington University in St. Louis, St. Louis, United States; 5Neurology,
Washingotn University in St. Louis, St. Louis, MO, United States
This
project investigated early biomarkers of Alzheimers disease (AD). In
particular, we studied the relationship between psychometrics (the Stroop
task) and blood oxygen level dependent resting state functional connectivity
magnetic resonance imaging (BOLD-fcMRI). We observed significant differences
in BOLD-fcMRI correlations between subjects with high and low COV subjects
within the default mode network (DMN). Our results suggest that psychometric
changes are associated with alterations in the DMN with both being early
markers for individuals at risk for AD.