Elena Gerasimovitch Steffensen1, Vineet
Prakash2, Simon Fristed Eskildsen3, Karsten Vestergrd4,
Victor Vishwanath Iyer2, Elna-Marie Larsson5
1Department of Radiology, Aalborg
Hospital/rhus University Hospital, Aalborg, Denmark; 2Department
of Nuclear Medicine, Aalborg Hospital/rhus University Hospital, Aalborg,
Denmark; 3Department of Health Science and Technology, Aalborg
University, Aalborg, Denmark; 4Department of Neurology, Aalborg
Hospital/rhus University Hospital, Aalborg, Denmark; 5Department
of Radiology, Uppsala University Hospital, Uppsala, Sweden
Introduction:
Volumetry and evaluation of WM damage is used to characterization of dementia.
Purpose: To investigate whether cortical/hippocampal volumetry; measurement
of mI- and NAA-concentration or FA and ADC is preferable in classification of
dementia. Method: 3T protocol: 3D T1-weighted imaging; 1H-spectroscopy and
DTI in 34 patients. 18FDG-PET: 9 FTD patients; 9-AD, 2- normal PET. Results:
Thinner cortex and higher ratio of mI/NAA was seen in posterior cingulate
cortex (PCC) for AD (p<0.05). FA was lower and ADC higher in FTD.
Conclusion: WM abnormalities have a potential to facilitate classification of
dementia. PCC may be chosen as a region of investigation.