Elena Gerasimovitch Steffensen1, Vineet Prakash2, Simon Fristed Eskildsen3, Karsten Vestergrd4, Victor Vishwanath Iyer2, Elna-Marie Larsson5
1Department of Radiology, Aalborg Hospital/rhus University Hospital, Aalborg, Denmark; 2Department of Nuclear Medicine, Aalborg Hospital/rhus University Hospital, Aalborg, Denmark; 3Department of Health Science and Technology, Aalborg University, Aalborg, Denmark; 4Department of Neurology, Aalborg Hospital/rhus University Hospital, Aalborg, Denmark; 5Department of Radiology, Uppsala University Hospital, Uppsala, Sweden
Introduction: Volumetry and evaluation of WM damage is used to characterization of dementia. Purpose: To investigate whether cortical/hippocampal volumetry; measurement of mI- and NAA-concentration or FA and ADC is preferable in classification of dementia. Method: 3T protocol: 3D T1-weighted imaging; 1H-spectroscopy and DTI in 34 patients. 18FDG-PET: 9 FTD patients; 9-AD, 2- normal PET. Results: Thinner cortex and higher ratio of mI/NAA was seen in posterior cingulate cortex (PCC) for AD (p<0.05). FA was lower and ADC higher in FTD. Conclusion: WM abnormalities have a potential to facilitate classification of dementia. PCC may be chosen as a region of investigation.