Michael K. Liem1, Saskia A.J. Lesnik Oberstein2, Maarten J. Versluis1, Joost Haan3, Andrew G. Webb1, Michel D. Ferrari3, Mark A. van Buchem1, Jeroen van der Grond1
1Radiology, Leiden University Medical Center, Leiden, Netherlands; 2Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands; 3Neurology, Leiden University Medical Center, Leiden, Netherlands
In this study we examined luminal diameters of lenticulostriate arteries in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Twenty-two CADASIL patients and 11 controls were examined using high resolution 3D-time-of-flight magnetic resonance angiography (TOF MRA) imaging on a 7-Tesla MRI scanner. No differences between CADASIL patients and controls were found in length, total number or total cross-sectional area of lenticulostriate artery lumina. Measurements of lenticostriate arteries were not associated with lacunar infarct load in the basal ganglia area.