Daniel Han-en Chang1, Jeon-Hor Chen1,2, Shadfar Bahri1, Hon J. Yu1, Ke Nie1, Orhan Nalcioglu1, Min-Ying Lydia Su1
1Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, United States; 2Department of Radiology, China Medical University Hospital, Taichung, Taiwan
Mammographic density is known to be strongly associated with the risk of breast cancer development, but using mammography to characterize breast density does not provide true volumetric information. MRI-based methods on the other hand provide promising alternatives, but may be affected by technical factors such as the choice of pulse sequences. We imaged breasts with two commonly used pulse sequences, fat-suppression and non-fat-suppression, and calculated their densities with an MRI-based method developed previously by our lab. We found that their densities are highly correlated and that fat-saturated images tend to have stronger relative tissue contrast.