Jeff Lei Zhang1, Eric E. Sigmund1, Hersh Chandarana1, Henry Rusinek1, Hua Guo1, Pippa Storey1, Qun Chen1, Vivian S. Lee1
1Department of Radiology, New York University, New York, NY, United States
Synopsis: To improve precision of bi-exponential parameters of diffusion weighted imaging (DWI), we proposed a method for optimizing b values for DWI acquisition. Monte Carlo simulation was performed to explore whether the optimized b values would improve the bi-exponential parameters ability in differentiating benign and malignant renal lesions. Results showed that, using the optimized b values, the differentiability of perfusion fraction for the two types of lesions improved by 22%7%, compared with uniformly distributed b values. The method should be applicable to DWI of any other tissues or organs where bi-exponential analysis is used.