Brian Keating1, Weiran Deng1, J Cooper Roddey2, Nathan White3, Anders Dale2, V Andrew Stenger1, Thomas Ernst1
1Department of Medicine, University of Hawaii, Honolulu, HI, United States; 2Department of Neuroscience, University of California at San Diego, La Jolla, CA, United States; 3Department of Cognitive Science, University of California at San Diego, La Jolla, CA, United States
Motion during brain 1H MR spectroscopy acquisitions can compromise spectral quality. We adapted an image-based adaptive motion correction module for use with a PRESS sequence. Sets of three orthogonal spiral navigator images are acquired in each TR period, to estimate head motion in real-time. By applying the appropriate rotations and translations, the voxel can be made to remain stationary with respect to the brain. Adaptive motion correction recovered original metabolite values (Cho/Cr ratio) to within a few percent even for extensive head movements (20-30), whereas non-navigated spectra showed marked changes in metabolite levels as well as increased variability.