Abstract #5034

Pulsed Continuous Arterial Spin Labeling (PCASL) with Prospective Motion Correction (PROMO)

Jian Zhang^1,2, Greg Zaharchuk², Michael Moseley², Eric Han³, Nate White⁴, Cooper Roddey⁴, Daniel Rettmann⁵, Anders Dale⁴, Joshua Kuperman⁴, Ajit Shankaranarayanan³

¹Department of Electrical Engineering, Stanford University, Stanford, CA, United States; ²Department of Radiology, Stanford University, Stanford, CA, United States; ³Global Applied Science Lab, GE Healthcare, Menlo Park, CA, United States; ⁴Department of Neuroscience, University of California, San Diego, La Jolla, CA, United States; ⁵Global Applied Science Lab, GE Healthcare, Rochester, MN, United States

Pulsed Continuous Arterial Spin Labeling (PCASL) is a promising whole-brain perfusion imaging technique, with good properties such as high efficiency, 3D multi-slice capability, and low hardware demands. However, this sequence is vulnerable to patient motions due to its long scan time. We demonstrate an improved perfusion imaging strategy by integrating the original PCASL sequence with a PROspective MOtion (PROMO) correction module. The new sequence is much more robust against brain motion with little interference between the imaging volume and PROMO navigators.