Daniel Jason Aaron Margolis1, Shyam Natarajan2, Dinesh Kumar3, Ram Narayanan3, Leonard Marks4
1Dept. of Radiology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA; 2Center for Advanced Surgical & Interventional Technology , UCLA David Geffen School of Medicine; 3Eigen; 4Dept. of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA
MRI with diffusion and perfusion imaging was performed in 54 consecutive men referred for prostate biopsy. Target lesions based on diffusion and perfusion parameters were ranked based on level of suspicion and contoured on T2-weighted imaging. Subsequent biopsies were performed with real-time image coregistration with transrectal ultrasound. The number of positive cores was significantly higher for targeted biopsies than for systematic 14-point sextant biopsies, and in some cases, cancer was only found with targeted biopsies.