Marco Borri1, Maria a Schmidt1, Matthew Blackledge1, Erica Scurr1, Elizabeth O'Flynn1, David Collins1, Matthew Orton1, Veronica Morgan1, Nandita de Souza1, Martin O. Leach1
Breast-DWI has been used in cancer diagnostic and monitoring of treatment response. Accurate calculation of Apparent Diffusion Coefficient(ADC) is essential and depends on the choice of b-values. In this work we utilise ADC data from large breast lesions to calculate optimal b-values, and compare protocols using different numbers of b-values. The calculated separation (1150s/mm2) is larger than the range of b-values used in many published clinical studies. Our data did not show significant advantage in the use of 2 b-values only, while a larger number of b-values could minimize artifacts and ensure correct sampling for a larger range of ADC-values.