Pairash Saiviroonporn1, Vip Viprakasit2,
Thananya Boonyasirinant3, Archrob Khuhapinant4, John C.
Wood5, Rungroj Krittayaphong3
1Radiology Department,
Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2Haematology/Oncology
Division, Department of Pediatrics & Thalassemia Center, Faculty of Medicine
Siriraj Hospital, Mahidol University; 3Division of Cardiology,
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol
University; 4Haematology/Oncology Division, Department of Internal
Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University; 5Divisions
of Cardiology, Department of Pediatrics, Childrens Hospital Los Angeles,
Keck School of Medicine, University of Southern California, United States
This study investigated inter-site observer variability of the Pixel-Wise (PW) method for cardiac T2* analysis in thalassemia patients using the mono-exponential with constant fitting (offset) model as well as to compare the offset model to the mono-exponential with median report (MPS). The inter-site variability of the offset model on the PW method provided acceptable CV on both scanning technique and was comparable to the conventional method. When comparing the offset to MPS method, the variability was also comparable to previous report for the black-blood technique but substantially higher for the bright-blood technique due to the discrepancy at low T2* range.