Matthew J. Middione1,2, Abbas N. Moghadam1,3, Yutaka Natsuaki4, Daniel B. Ennis1,5
1Department of Radiological Sciences, Diagnostic Cardiovascular Imaging Section, University of California,, Los Angeles, CA, United States; 2Biomedical Physics Interdepartmental Program, University of California, Los Angeles, CA, United States; 3Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic),, Tehran, Iran; 4Siemens Medical Solutions, Malvern, PA, United States; 5Biomedical Physics Interdepartmental Program, University of California,, Los Angeles, CA, United States
Chemical shift artifacts can corrupt blood flow quantification in Phase Contrast MRI (PC-MRI). Specifically, perivascular fat can chemically shift across the vessel wall and into the lumen, thereby leading to over or underestimation of blood velocity within a vessel, depending on the imaging protocol. The degree to which chemical shift disrupts blood flow measurements depends on the readout bandwidth and the echo time. We propose that using a higher readout bandwidth reduces chemical shift artifacts in PC-MRI and concomitantly improves the accuracy of quantitative blood flow measurements.