Guangyu Chen1, Chunming Xie1, Gang Chen1, Barney Douglas Ward1, Wenjun Li1, Piero Antuono2, Shi-Jiang Li3
1Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 2Neurology, Medical College of Wisconsin, Milwaukee, WI, United States; 3Psychiatry & Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, United States
The correlation between global signal and all brain voxel's time series which are not regressed out the global signal can reveal the distribution pattern of global signal in brain. The significant correlation between global signal distribution and behavior score such as Geriatric Depression Scale (GDS) and Rey Auditory Verbal Learning Test (RAVLT) indicates that global signal has biological significance. And we found that the different distribution pattern between healthy and mild cognitively impaired brain is primary overlapped with default mode network.