Joseph Goveas1, Chunming Xie2,3, Gang Chen2, Wenjun Li2, B. Douglas Ward2, Guangyu Chen2, Jennifer Jones4, Malgorzata Franczak4, Piero Antuono4, Shi-Jiang Li2
1Psychiatry & Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, United States; 2Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 3Neurology, School of Clinical Medicine, Southeast University, Nanjing, Jiangsu, China, People's Republic of; 4Neurology, Medical College of Wisconsin, Milwaukee, WI, United States
Apolipoprotein E-&4 (ApoE-&4) carriers are at an increased risk for incident late-onset Alzheimers disease (AD). While diminished default mode network (DMN) functional connectivity is observed in AD, increased DMN connections to medial and dorsolateral prefrontal cortices and medal temporal lobe regions, and decreased connectivity to precuneus are reported in ApoE-&4 carriers. We examined if ApoE-&4 carriers will show alterations in the DMN, executive control (ECN) and salience networks (SN), relative to ApoE-&4 non-carriers.