Jerry S. Cheung1, Enfeng Wang1, Giulia Fulci2, Phillip Zhe Sun1
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH & Harvard Medical School, Charlestown, MA 02129, United States; 2Molecular Neuro-oncology Laboratories, Center for Molecular Imaging, MGH & Harvard Medical School, Boston, MA 02124, United States
T1 and T2 MRI are widely used MRI parameters in monitoring tumor progression and treatment response, yet unambiguous demarcation of tumor from peritumoral edema is often difficult due to diffuse tumor boundary. Given that both T1 and T2 of tumor and edema alter to different extent, we postulate that T1 over T2 (TOT) map may augment conventional relaxation time imaging. Our data showed that T1/T2 better depicted brain tumor region by suppressing signal from peritumoral edema and CSF, in good agreement with Gadolinium-enhanced MRI.