Sean Foxley1, Xiaobing Fan1, Jonathan River1, Marta Zamora1, Erica Markiewicz1, Shunmugavelu Sokka2, Gregory S. Karczmar1
1Department of Radiology, University of Chicago, Chicago, IL, United States; 2MR-HIFU, Philips Healthcare, Andover, MA, United States
This pilot study investigates physiological effects of locally induced hyperthermia in a rodent tumor model using high spectral and spatial resolution MRI. Approximately 6 C increases were produced in tumor tissue using fiber optic guided light from a halogen lamp. Time dependent changes in water resonance peak width were measured during 15 minutes of localized tumor heating. Hyperthermically induced quantitative differences between tumor tissue and normal muscle were measured. Results suggest that response to hyperthermia measured by MRI could be used diagnostically to identify and/or characterize suspicious lesions and guide development of new hyperthermia protocols.