R. Marc Lebel1, Jesse Jones2, Jean-Christophe Ferr2, Samuel Valencerina2, Krishna S. Nayak1, Meng Law2
1Department of Electrical Engineering, University of Southern California, Los Angeles, CA, United States; 2Department of Radiology, University of Southern California, Los Angeles, CA, United States
Dynamic contrast enhanced (DCE) imaging requires high spatial and temporal resolution and large volume coverage; traditionally, these are mutually exclusive. We present prospective undersampled DCE imaging of brain tumors with high spatiotemporal resolution using l1-SPIRiT (compressed sensing and parallel imaging). We employ multiple spatial and temporal reconstruction constraints, including a novel temporal constraint that promotes low frequency signal changes, to achieve high accelerations without compromising resolution or dynamic information.