Marta Morgado Correia1, Charlotte Rae1, Ellemarije Altena2, Laura Hughes1, 2, James Rowe1, 2
1Cognition and Brain Sciences Unit, Medical Research Council, Cambridge, Cambridgeshire, United Kingdom; 2Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
In this diffusion MRI study we used TBSS and VBM methods to compare a group of PD patients to an age and gender matched set of controls, and we aimed to determine which of those techniques is most sensitive in detecting white matter changes in Parkinsons patients. Using TBSS we replicated previous studies and have also shown more widespread cortical white matter pathology in PD. The VBM method found no regions of significantly decreased FA or increased MD in patients that survive FDR correction for multiple comparisons, suggesting that TBSS is more sensitive to white matter changes in PD patients.