Sanaz Mohajeri1, 2, Tedros Bezabeh1, Scott B. King1, Omkar B. Ijare1, M.A. Thomas3, Gerald Minuk2, Jeremy Lipschitz2, Allan B. Micflikier2, Iain Kirkpatrick2, Lawrence Ryner1, Ian C.P. Smith1
1National Research Council, Institute for Biodiagnostics, Winnipeg, Manitoba, Canada; 2University of Manitoba, Winnipeg, Manitoba, Canada; 3University of California, Los Angeles
Cholestasis results from failure to clear bile from the liver into the duodenum. Prolonged cholestasis results in accumulation of bile salts and hepatocellular damage. Phosphatidylcholine and glycine/taurine conjugated bile acids may play a role in the pathophysiology of cholestasis. Primary Scelerosing Cholangitis (PSC) is a chronic cholestatic liver disorder with inflammation, narrowing and finally obstruction of bile ducts. Considering the success of in vivo 1-H MRS in detecting human bile components, we are comparing in this study 1-D and 2-D spectra of human bile in healthy volunteers and PSC patients obtained using a 3T clinical scanner and our home-built receive array coil.