Alexander Peter Lin1, Sai Merugumala2, Saadallah Ramadan3, Huijun Liao2, Paolo Fiorina4, Anil Chandraker5, Carolyn Mountford2, 6
1Radiology, Center for Clinical Spectroscopy , Brigham and Women's Hospital , Boston, MA, United States; 2Radiology, Center for Clinical Spectroscopy, Brigham and Women's Hospital, Boston, MA, United States; 3Centre for MR in Health, University of Newcastle, Callaghan, New South Wales, Australia; 4Transplant Research Center, Childrens Hospital Boston, Boston, MA, United States; 5Renal Division, Brigham and Women's Hospital, Boston, MA, United States; 6Centre for MR in Health, University of Newcastle, Callaghan , New South Wales, Australia
There is a need to identify early biomarkers of transplanted kidney dysfunction that are non-invasive. This study describes the optimization of one-dimensional and novel two-dimensional magnetic resonance spectroscopy methods to identify such biomarkers. The results showed that acquisition using a phased array torso coil, weak water suppression with water reference, voxel size of 13.5cc, and 2D COSY scan time of 11 minutes provided metabolite measurements of choline, triglycerides, unsaturated fatty acids, olefinic fat, methylene and methyl fat resonances. These results provide the basis for future studies to determine the potential of these metabolic biomarkers in early detection and treatment monitoring.