Ronald Ouwerkerk1, Ahmed Medhat Gharib2
1Metabolic Imaging Branch, NIDDK/NIH, Bethesda, MD, United States; 2Metabolic Imaging Branch, NIH/NIDDK, Bethesda, MD, United States
Metabolites in the pancreas of healthy human subjects were measured with single volume PRESS 1H-MRS. In one subject the T2 relaxation times for lipid, choline and water were determined. Breath hold B0 field mapping improved spectral quality and navigator gated suppression of breathing motion helped avoid spurious lipid signals from surrounding tissues. Spectra contained signals of choline at 3.2 ppm, creatine at 3.0 ppm, and possibly glycerol, glucose or glycogen. The concentration of choline was 17.57.0 mmol/l (N=7, range 7.4-25.1). The T2 relaxation times for lipid choline and water were 101, 98 and 48 ms respectively in one subject.