Christian Ros1, Hellmuth Ricardo Muller-Moran2, Daniel Gllmar1, Martin Stenzel3, Hans-Joachim Mentzel3, Jrgen Rainer Reichenbach1
1Medical Physics Group, Department for Diagnostic and Interventional Radiology I, Jena University Hospital, Jena, Thuringia, Germany; 2McGill University, Montreal, Quebec, Canada; 3Pediatric Radiology, Department for Diagnostic and Interventional Radiology I, Jena University Hospital, Jena, Thuringia, Germany
With this contribution we present a new tractography-based estimation technique to determine the error of co-registration techniques. Acquired datat sets are used as gold standard (GS). Displacement fields are then utilized to generate prototype data sets (PDS). These PDS are co-registered to the GS and transformed back to the original space. Due to the one-to-one correspondance of the fiber tracts, that were transformed as well, the error can be exactly determined. The technique was used to evaluate the ANTs co-registration framework, in order to determine optimal registration parameter as well as suitable contrasts for the co-registration of white matter regions.