1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 2Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands
Variations in the signal intensity of citrate and other metabolites in 1H MRSI of the prostate may be caused by changes in luminal volume. This was investigated for cancer containing prostates by correlating signal intensities with morphological features of digitally segmented histopathological slices. A significant relation was found between the Cho+Spm+Cr/Cit ratio and the %area-of-nuclei / %-area-of-lumen, obtained from HE stained slices of prostatectomy samples. This study indicates that changes in the signal of Cit (and possibly of other metabolites) in PCa result from morphological alterations, rather than changes in metabolism.