Sophie F. Riches1, Geoffrey S. Payne1, Nandita M. deSouza1, Scott Morgan2, David Dearnaley3, Veronica A. Morgan1, Sharon L. Giles1, Mike Partridge4
1CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; 2Division of Radiation Oncology, University of Ottawa, Ottawa, Ontario, Canada; 3Division of Radiotherapy & Imaging, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; 4Gray Institute for Radiation Oncology and Biology,Department of Oncology, University of Oxford, Oxford, Oxfordshire, United Kingdom
The use of a boosted radiation dose to a tumour nodule within the prostate is limited by poor accuracy for tumour localisation on morphological imaging; functional imaging offers more accurate delineation of the dominant intraprostatic lesion. This study uses a model that combines multifunctional MR parameters to define an intraprostatic lesion and plans an 84 Gy radiation boost to functional imaging-defined tumour with IMRT. Compared to a standard clinical treatment of 72 Gy applied uniformly across the prostate, a focal boost resulted in a greater therapeutic ratio, with potentially greater tumour control and fewer side-effects from the treatment.