Sundar Gnanavel1, Pratap Sharan2, Sudhir Khandelwal2, Uma Sharma3, Jagannathan NR4, Rani Gupta Sah4
1Psychiatry, AIIMS, New Delhi, Select State, India; 2Psychiatry, AIIMS, New Delhi, Delhi, India; 3NMR, AIIMS, New Delhi, Select State, India; 4NMR, AIIMS, New Delhi, Delhi, India
The study aims to demonstrate alterations in neurochemical measures that are specific to obsessive compulsive disorder (OCD) using invivo proton MRS of caudate nucleus, anterior cingulate cortex (ACC) and medial thalamus in patients of OCD and to identify their role as vulnerability markers by comparing them with the healthy first degree relatives of these patients and healthy controls. There were significant group differences in two of the three regions of interest: caudate nucleus and ACC. The study results support the neurodegenerative hypothesis of OCD and possibility of use of these bio-chemicals as putative markers that may aid in early intervention.