Scott K. Nagle1, 2, Laura C. Bell3, Mark L. Schiebler1, Christopher J. Francois4, James H. Holmes5, Sean B. Fain, 12, Kang Wang5
1Radiology, University of Wisconsin, Madison, WI, United States; 2Medical Physics, University of Wisconsin, Madison, WI, United States; 3Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 4Radiology, University of Wisconsin-Madison, Madison, WI, United States; 5Global Applied Science Laboratory, GE Healthcare, Madison, WI, United States
Quantitative contrast-enhanced pulmonary perfusion MRI has been limited by the need for high temporal-spatial resolution, full-lung coverage, and the need to scan within a reasonable length breath-hold. The purpose of this work was to compare the performance of 3 different Cartesian under-sampling methods in combination with 2 alternative reconstruction methods to perform whole-chest, time-resolved pulmonary perfusion MRI with isotropic 4mm resolution and 0.5-1s temporal resolution. Qualitative assessment of image quality at peak parenchymal enhancement was comparable. However, quantitative assessment of the contrast enhancement curves showed higher maximum values, steeper up-slopes, and shorter rise-times using HYCR rather than view-sharing reconstruction.