Naomi Santa Maria1, Thomas Ng, Sharon Lin, Sarah McCaig2, Desiree Crow2, Jianyi Wang2, Andrew Raubitschek2, Russell E. Jacobs
1Biology, Caltech, Pasadena, CA, United States; 2City of Hope, Duarte, CA, United States
MRI can provide a noninvasive tool to characterize adoptive NK cell therapy. We aimed to implement MRI-based NK cell tracking methods that could be clinically translatable by using an FDA-approved USPIO cell label on NK cells isolated from human peripheral blood. MRI as a noninvasive in vivo cellular imaging technique could further elucidate optimization of adoptive NK cell transfer as a cancer therapy.