Harshan Ravi1, 2, Jinsoo Uh3, Peiying Liu1, Lisa C. Krishnamurthy1, 2, Hanzhang Lu1
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Department of Bioengineering, University of Texas at Arlington, Arlington, TX, United States; 3Department of Radiological Sciences, St. Jude Childrens Research Hospital, Memphis, TN, United States
Venous blood oxygenation is an important parameter for the quantification of cerebral metabolic rate of oxygen (CMRO2), a key biomarker for brain tissue viability and functionality. T2 based methods has been reported to measure Yv in macroscopic veins. However, the oxygenation of microvasculature (capillary/venule), which renders spatially more specific information, is not yet investigated. In this study we propose a novel technique to isolate microvascular venous blood signal and measure its oxygenation, named micro-vasculature T2-relaxation-Under-Spin-Tagging (mTRUST). This technique complements and extends the applicability of existing methods targeting macroscopic veins, and may lay foundation to region specific CMRO2 mapping in future.