Joost P. A. Kuijer1, Larissa W. van Golen2, Marc C. Huisman3, Richard G. IJzerman2, Frederik Barkhof3, Michaela Diamant2, Adriaan A. Lammertsma3
1Physics and Medical Technology, NCA, VU University Medical Center, Amsterdam, NL, Netherlands; 2Diabetes Center, Internal Medicine, VU University Medical Center, Amsterdam, NL, Netherlands; 3Radiology and Nuclear Medicine, NCA, VU University Medical Center, Amsterdam, NL, Netherlands
Arterial Spin Labeling (ASL) was compared with H215O Positron Emission Tomography (PET), the current gold standard for non-invasive quantification of CBF, in patients with type 1 diabetes and healthy subjects. The ASL variant used was pseudo-continuous, with background suppression, and a 3D FSE spiral readout. Both methods were compared in terms of absolute quantification and regional differences.