Valentina Di Marco1, Marco Palombo1, 2, Silvia Capuani1, 2
1Physics Department, Sapienza University, Rome, Italy; 2CNR IPCF UOS Roma, Physics Department, Sapienza University, Rome, Italy
We investigated the potential of Gaussian and non-Gaussian diffusion methods to obtain information about the microstructural complexity and the water compartmentalization in free and trabecular bone-marrow by investigating apparent diffusion coefficient (ADC) of the water and the fat component as a function of diffusion time (&[Delta]). ADCs of the fat were found to be constant as a function of &[Delta], while the intracellular and the extracellular water exhibits a different ADC behavior as a function of &[Delta] in free and trabecular bone marrow. Internal gradient at the interface between water and bone affects extracellular ADC behaviour which is non-Gaussian.